Antibiotic-impregnated acrylic bone cement.

  title={Antibiotic-impregnated acrylic bone cement.},
  author={Kenneth E. Marks and Carl L Nelson and Eugene P. Lautenschlager},
  journal={The Journal of bone and joint surgery. American volume},
  volume={58 3},
In vitro and in vivo experiments were performed to study the antibacterial and mechanical properties of Simplex and Palacos acrylic bone cements utilized for the production of acrylic cement-antibiotic composites. Acrylic cement without antibiotic had no bacteriostatic effect on Staphylococcus aureus, Escherichia coli, and Pseudomonas. Oxacillin, cefazolin, and gentamicin are stable in acrylic cement and are released in a microbiologically active form. The three antibiotics diffused from the… CONTINUE READING

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