Antibiotic doxorubicin and its derivative bind milk β-lactoglobulin.

Abstract

β-Lactoglobulin (β-LG) is a member of lipocalin superfamily of transporters for small hydrophobic molecules such as doxorubicin and its derivatives. We located the binding sites of doxorubicin (DOX) and N-(trifluoroacetyl) doxorubicin (FDOX) with β-lactoglobulin in aqueous solution at physiological conditions, using FTIR, CD and fluorescence spectroscopic… (More)
DOI: 10.1016/j.jphotobiol.2012.09.014

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