Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species).

@article{Gilbert2005AntibioticCO,
  title={Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species).},
  author={Jeffrey Gilbert and Charles K. Nfon and Benjamin L. Makepeace and Leo M. Njongmeta and Ian M. Hastings and Kenneth M Pfarr and Alfons Renz and Vincent N. Tanya and Alexander J. Trees},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={192 8},
  pages={1483-93}
}
Development of a drug lethal to adult Onchocerca volvulus (i.e., macrofilaricide) is a research priority for the control of human onchocerciasis. Using bovine O. ochengi infections, we investigated the effects of oxytetracycline administered in a short intensive regimen (SIR; 10 mg/kg daily for 14 days), compared with a prolonged intermittent regimen (PIR; 20 mg/kg monthly for 6 months) or a combination of both (COM), on the viability of adult worms and their endosymbiotic bacteria (Wolbachia… CONTINUE READING