Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata.

@article{Socha2006AntibioticBP,
  title={Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata.},
  author={Aaron M. Socha and Dioscaris R Garcia and Roberta Sheffer and David C. Rowley},
  journal={Journal of natural products},
  year={2006},
  volume={69 7},
  pages={1070-3}
}
Chemical studies of a streptomycete isolated from a cyanobacterium associated with the tropical tunicate Ecteinascidia turbinata led to the bioassay-guided purification of two antibacterial bisanthraquinone metabolites and a cytotoxic artifact. The structures, including relative configurations of these octacyclic compounds, were established by spectroscopic analyses. Their potent antibacterial properties (IC(50) = 0.15-130 microM) versus methicillin-resistant Staphylococcus aureus and… CONTINUE READING