Antibiotic and Cytotoxic Activity of Brominated Compounds from the Marine Sponge Verongia aerophoba

  title={Antibiotic and Cytotoxic Activity of Brominated Compounds from the Marine Sponge Verongia aerophoba},
  author={R. Teeyapant and Herman J. Woerdenbag and Peter Kreis and J K Hacker and Victor Wray and Ludger Witte and Peter Proksch},
  journal={Zeitschrift f{\"u}r Naturforschung C},
  pages={939 - 945}
Abstract Analysis of the marine sponge Verongia aerophoba from the Canary Islands afforded eight brominated secondary metabolites including the small molecular weight compounds aeroplysinin-1 (5) and the dienone (7) which were previously shown to arise by enzymatically catalyzed degradation of aerophobin-2 (4) and isofistularin-3 (1) following breakdown of the cellular compartmentation of the sponge. All compounds were identified from their NMR and mass spectra. Aeroplysinin-1 as well as… Expand
Defense metabolites from the marine sponge Verongia aerophoba
Aeroplysinin-1 and dienone were shown to exhibit pronounced biological activities in various bioassays with marine organisms whereas their biogenetic precursors isofistularin-3 and aerophobia were either inactive or exhibited only marginal activity. Expand
Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides.
Extracts of cultures grown in liquid or on solid rice media of the fungal endophyte Ampelomyces sp. isolated from the medicinal plant Urospermum picroides exhibited considerable cytotoxic activityExpand
Marine biomaterials: Biomimetic and pharmacological potential of cultivated Aplysina aerophoba marine demosponge.
The aim of this work was to simultaneously isolate selected bromotyrosines and unique chitinous structures from A. aerophoba and to propose these molecules and biomaterials for possible application as antibacterial and antitumor compounds and as ready-to-use scaffolds for cultivation of cardiomyocytes, respectively. Expand
Bioactive natural products from marine sponges and fungal endophytes
The activated chemical defence of the Mediterranean sponge Aplysina aerophoba is introduced as an example of a dynamic response of marine sponges to wounding and a preliminary characterization of the membrane bound enzyme(s) involved in the cleavage reaction is presented. Expand
An Aeroplysinin-1 Specific Nitrile Hydratase Isolated from the Marine Sponge Aplysina cavernicola
The enzymes were shown to be manganese dependent, although cobalt and nickel ions were also able to recover the activity of the nitrile hydratases, and showed high substrate specificity towards the physiological substrate aeroplysinin-1. Expand
Expression of secondary metabolites by the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola
The methodology to quantify the major secondary metabolites produced by the two Mediterranean Aplysina species is finalized, chemotaxonomic markers are identified in order to clearly discriminate the two sibling species, and the role of microbial symbionts in bromotyrosine alkaloids biosynthesis is investigated. Expand
Temporal Trends in the Secondary Metabolite Production of the Sponge Aplysina aerophoba
The present study is one of the first to document quantitative seasonal variations in individual compounds over multiple years, and the role of environmental, biological, and physiological factors in determining the seasonal patterns in the concentration of brominated alkaloids is clarified. Expand
Activated Chemical Defense in Aplysina Sponges Revisited
It is concluded that tissue damage induces a bioconversion of isoxazoline alkaloids into aeroplysinin-1 and dienone in Aplysina sponges, and this reaction is likely catalyzed by enzymes, and it may be ecologically relevant as theBioconversion products possibly protect the wounded sponge tissue from invasion of bacterial pathogens. Expand
Natural Products from Sponges
Development of recombinant microorganisms engineered for efficient production of sponge-derived products is a promising strategy that deserves further attention in future investigations in order to address the limitations regarding sustainable supply of marine drugs. Expand
Ex situcultivation ofAplysinaaerophobaclose toin situconditions: ecological, biochemical and histological aspects
Although sponges showed slight reduction during maintenance, ex situ cultivation similar to in situ conditions provides a promising method to keep spongees and obtain their bioactive metabolites. Expand


The Search for Antiviral and Anticancer Compounds from Marine Organisms
A survey is presented of the occurence of compounds from marine source, other than microorganisms, which have been reported to have antiviral, antitumor or cytotoxic properties. The biological dataExpand
Sec­ ondary Metabolites from Marine Sponges
  • Ullstein Mosby, Berlin
  • 1993
  • Apoth. Ztg. 132, 673
  • 1992
Current Status: The Socorro isopod is listed as a federal endangered species (Federal Register 1994). In August 1988, T. thermophilum was extirpated in the wild when diminished discharge of theExpand