Antibiotic-acrylic bone cement composites. Studies of gentamicin and Palacos.

  title={Antibiotic-acrylic bone cement composites. Studies of gentamicin and Palacos.},
  author={David J. Schurman and Cleide Enoir Petean Trindade and H P Hirshman and Kenneth Moser and Glen Kajiyama and P. P. Wilkens Stevens},
  journal={The Journal of bone and joint surgery. American volume},
  volume={60 7},
Palacos bone cement with and without contained gentamicin was tested for antibacterial efficacy using a rabbit model of a knee hemiarthroplasty and a challenge with intra-articular Escherichia coli. The gentamicin-containing cement prevented infection from challenge with Escherichia coli and protected against inadvertent operative infection as well. Antibiotic concentrations in synovial fluid and urine remained in the therapeutic range for three days, whereas levels in serum were always quite… CONTINUE READING

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