Antibiotic Treatment Selects for Cooperative Virulence of Salmonella Typhimurium

@article{Diard2014AntibioticTS,
  title={Antibiotic Treatment Selects for Cooperative Virulence of Salmonella Typhimurium},
  author={M{\'e}d{\'e}ric Diard and Mikael Erik Sellin and Tamas Dolowschiak and Markus Arnoldini and Martin Ackermann and Wolf-Dietrich Hardt},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={2000-2005}
}
Antibiotics are powerful therapeutics but are not equally effective against all cells in bacterial populations. Bacteria that express an antibiotic-tolerant phenotype ("persisters") can evade treatment [1]. Persisters can cause relapses of the infection after the end of the therapy [2]. It is still poorly understood whether persistence affects the evolution of bacterial virulence. During infections, persisters have been found preferentially at particular sites within the host [3, 4]. If… CONTINUE READING
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