Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana.

@article{Smith2007AntibacterialsAM,
  title={Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana.},
  author={Eileen C J Smith and Elizabeth M. Williamson and Neale Wareham and Glenn W Kaatz and Simon Gibbons},
  journal={Phytochemistry},
  year={2007},
  volume={68 2},
  pages={210-7}
}
As part of an on-going project to characterize compounds from immature conifer cones with antibacterial or modulatory activity against multidrug-resistant (MDR) strains of Staphylococcus aureus, eight compounds were isolated from the cones of Chamaecyparis lawsoniana. The active compounds were mainly diterpenes, with minimum inhibitory concentrations ranging from 4 to 128 microg/ml against MDR effluxing S. aureus strains and two epidemic methicillin-resistant (EMRSA) clinical isolates. The… CONTINUE READING
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