Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans

  title={Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans},
  author={Nantiya Joycharat and Sonesay Thammavong and Surasak Limsuwan and Sirilux Homlaead and Supayang P. Voravuthikunchai and Boon-Ek Yingyongnarongkul and Sukanya Dej-adisai and Sanan Subhadhirasakul},
  journal={Archives of Pharmacal Research},
Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries. In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3′,4′-trihydroxyflavone (7), and 7,8,3′,4′-tetrahydroxyflavone (8), a triterpenoid lupeol (3) as well as four sterols β-sitosterone (1), stigmasta-5,22-dien-3-one (2), β-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds… 

Chemical constituents and biological activities of Albizia myriophylla wood

This is the first report of compounds 1–4 from A. myriophylla, a medicinal plant widely used in Thailand and other Asian countries as a folk medicine remedy for many ailments, which showed potent antibacterial and cytotoxic activities compared with other isolates.

α-Glucosidase inhibitory, antibacterial, and antioxidant activities of natural substances from the wood of Derris reticulata Craib

The phytochemical investigation of the wood of D. reticulata revealed the isolation of two new pyranoflavanones, 4'-methoxydereticulatin and 2'''-hydroxy,3'''-ethoxylupinifolin, along with five known compounds, which displayed good activity against four out of five tested pathogenic bacterial strains.

Alpha-glucosidase inhibitory activity of ethanol extract, fractions and purified compounds from the wood of Albizia myriophylla

The plant ethanol extract and its different fractions possessed α-glucosidase inhibitory activity in a concentration-dependent manner and it was proved that indenoic acid, 8-methoxy-7, 3′,4′-trihydroxyflavone and 3,4,7,3′-tetrahydroxyflavan were partially rational for antidiabetic effect of this plant species.

Expediency of Flea Tree (Albizia lebbeck L.) in the prevention of known human fungal and bacterial strains

The study concluded that A. lebbeck have significant antimicrobial potential and might be helpful in antibiotics.

Antibacterial Activity of Lupinifolin from Derris reticulata and Its Effect on Cytoplasmic Membrane of Methicillin Resistant

The lupinifolin showed minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 8 and 16 μg/ml against Methicillin resistant S. aureus (MRSA) and has no effect on DNA fragmentation.

Lupinifolin from Derris reticulata possesses bactericidal activity on Staphylococcus aureus by disrupting bacterial cell membrane

It was found that lupinifolin possessed antimicrobial activity against S. aureus with minimum inhibitory concentration and minimum bactericidal concentration, which is less potent than ampicillin.

Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity

The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling. Three

Antidiarrhoeal evaluation of root extract, its bioactive fraction, and lupinifolin isolated from Eriosema chinense.

The ethanol extract, chloroform fraction, and lupinifolin demonstrated a significant recovery from Na+ and K+ loss and a pronounced antibacterial activity against bacterial strains mainly implicated in diarrhoea.

Stem extract of Albizia richardiana exhibits potent antioxidant, cytotoxic, antimicrobial, anti-inflammatory and thrombolytic effects through in vitro approach

The extract showed a moderate LC50 value in brine shrimp lethality bioassay, where the CTFAR extract exhibited potential antimicrobial activities against sixteen different microorganisms, and wide spectrum of antimicrobial activity.



Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.

Effects of Compounds Found in Propolis on Streptococcus mutans Growth and on Glucosyltransferase Activity

Apigenin is a novel and potent inhibitor of GTF activity, and tt-farnesol was found to be an effective antibacterial agent.

In vitro anti-cariogenic activity of dichloromethane fraction fromRheum undulatum L. root

Results indicate that DF is probably useful for the control of dental plaque formation and subsequent dental caries development and may be related to the presence of anthraquinones, cardiac glycosides, coumarines, sterols/terpenes, and phenolics.

The potential use of propolis as a cariostatic agent and its actions on mutans group streptococci.

The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera.

Potent anticariogenic activity of Aceriphyllum rossii and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid.

The results suggest that the methanol extract of A. rossii root and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid, could have the great potential as natural agents for preventing dental caries.

Antimicrobial activity against oral pathogens and immunomodulatory effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith

Investigating the antimicrobial activity of M. fasciculata geopropolis against oral pathogens, its effects on S. mutans biofilms, and the chemical contents of the extracts concluded that a geopropolis-based gel is not toxic in an animal model and displays anti-inflammatory effect.

Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens.

Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker

Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC50 value of AlbizIA lebBeck was found to be 85 μg/ml.


The propolis extract possesses in vivo antimicrobial activity against S. mutans present in the oral cavity and might be used as an alternative measure to prevent dental caries.