Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas.

  title={Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas.},
  author={Michael H. Cullen and N Blair Steven and Lucinda Billingham and C. Gaunt and M. J. G. Hastings and Peter Simmonds and Nicholas Stuart and Daniel William Rea and Mark Bower and Indrajit Fernando and Robert A Huddart and Simon William Gollins and Andrew Stanley},
  journal={The New England journal of medicine},
  volume={353 10},
BACKGROUND The role of prophylactic antibacterial agents after chemotherapy remains controversial. METHODS We conducted a randomized, double-blind, placebo-controlled trial in patients who were receiving cyclic chemotherapy for solid tumors or lymphoma and who were at risk for temporary, severe neutropenia (fewer than 500 neutrophils per cubic millimeter). Patients were randomly assigned to receive either 500 mg of levofloxacin once daily or matching placebo for seven days during the expected… CONTINUE READING
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