Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro

  title={Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro},
  author={Outi Lepp{\"a}ranta and Minna Vaahtio and Timo Peltola and Di Zhang and Leena Hupa and Mikko Hupa and Heimo O. Yl{\"a}nen and Jukka I Salonen and Matti K. Viljanen and Erkki Eerola},
  journal={Journal of Materials Science: Materials in Medicine},
Bioactive glasses (BAGs) of different compositions have been studied for decades for clinical use and they have found many dental and orthopaedic applications. Particulate BAGs have also been shown to have antibacterial properties. This large-scale study shows that two bioactive glass powders (S53P4 and 13–93) and a sol–gel derived material (CaPSiO II) have an antibacterial effect on 17 clinically important anaerobic bacterial species. All the materials tested demonstrated growth inhibition… 
Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method
Background: Infection constitutes the most important complication caused by biomaterials. Bioactive glasses have properties such as osteoconductivity and good restorability, some of which have
Antibacterial Properties of Bioactive Glasses
Nanosized bioactive glasses, ion and natural organic substances and blended/doped bioactive glasses have been gaining growing attention due to their superior osteoconductivity and antibacterial
Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review
The use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure.
Study on antibacterial effect of 45S5 Bioglass®
The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates.
In vitro Study of the Antibacterial Activity of Bioactive Glass‐ceramic Scaffolds
Staphylococcus aureus is an opportunistic pathogen of major clinical interest for its high prevalence in biomaterial-related infections. This experimental study provides the first evidence in vitro
Broad-spectrum bactericidal activity of a new bioactive grafting material (F18) against clinically important bacterial strains.
Both doped and non-doped glasses demonstrated very high bactericidal activity, making F18 a promising infection-preventing alternative for bone and wound regeneration in clinical practice.
S53P4 bioactive glass
Bioactive glasses (BAGs) are synthetic bone graft substitutes that have been investigated by various orthopedic research groups in the past decades. These bone-bonding, osteoconductive materials can
Bioactive glasses and calcium phosphates
Abstract The use of bioceramics in the human body, including bioactive glasses and calcium phosphates, has revolutionized the research in biomedical field. These biomaterials are not only employed
Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects.
Results show that strontium-substituted bioactive glasses significantly promote osteogenic responses of MC3T3-E1 osteoblast-like cells and inhibit the growth of A. actinomycetemcomitans and P. gingivalis.
Antibacterial effect of morphous (poly-crystalline) and amorphous (glass) nano-bioactive glass 45S5 on Streptococcus mutans
Objective: Bioactive glass 45S5 is a surface reactive glass-ceramic biomaterial, developed in 1969. BAG 45S5 with particle size of 20-60 nm has the ability of bone regeneration, broad spectrum


Bactericidal effects of bioactive glasses on clinically important aerobic bacteria
Bioactive glasses were found to clearly inhibit the growth of a wide selection of bacterial species causing e.g., infections on the surfaces of prostheses in the body after implantation.
Effect of Ion Release on Antibacterial Activity of Melt-Derived and Sol-Gel-Derived Reactive Ceramics
Four different bioreactive ceramics were prepared using a sol-gel method and a standard melting process. The aim was to study antibacterial effect of these materials on the growth of Staphylococcus
Factors Controlling Antibacterial Properties of Bioactive Glasses
Factors controlling the antibacterial ability of three bioactive glasses were studied by comparing the changes in the SBF during immersion of the glasses with their response to four microorganisms.
Broad-Spectrum Bactericidal Activity of Ag2O-Doped Bioactive Glass
An initial investigation of the in vitro antibacterial properties of AgBG, a novel bioactive glass composition doped with Ag2O, finds that it was bacteriostatic and bactericidal, but it also elicited a rapid bactericidal action.
Antibacterial activity of particulate bioglass against supra- and subgingival bacteria.
It was found that the viability of S. sanguis was significantly reduced following exposure to NB pre-incubated with Bioglass, and neutralisation of this highly alkaline solution eliminated the antibacterial effect.
In Vitro Characterization of Bioactive Glasses
In vitro behavior of 30 new glasses in the system Na2O-K2O-MgO-CaO-B2O3 -P2O5-SiO2 was investigated by immersing them into a simulated body fluid for 4 to168 hours. This study involved the
Antibacterial effects of a bioactive glass paste on oral microorganisms.
In aqueous solutions the powdered bioactive glass S53P4 appears to have a broad antimicrobial effect on microorganisms of both supra- and subgingival plaque, which could be useful as an ingredient in tooth-care products that may have beneficial effects on oral health both from a cariologic and a periodontal point of view.
Antibacterial and bioactive silver-containing Na2O·CaO·2SiO2 glass prepared by sol–gel method
High antimicrobial effects of samples against Escherichia coli and Streptococcus mutans were found and FTIR measurements and SEM micrographs have ascertained the formation of a hydroxyapatite layer on the surface of samples soaked in a simulated body fluid for different times.
In Vitro Attachment of Staphylococcus Epidermidis to Surgical Sutures with and without Ag-Containing Bioactive Glass Coating
This preliminary study has demonstrated the quantification and visualization of bacterial attachment onto sutures in order to compare the antibacterial properties of Ag-containing bioactive glass coatings.
Direct chemical bond of bioactive glass-ceramic materials to bone and muscle.
The objective of this research is to achieve direct chemical bonding of structurally strong implant materials with hard and soft tissues. This objective has been achieved through the development of a