Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.

@article{Wang2012AntibacterialBF,
  title={Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.},
  author={Weihong Wang and Hiyoung Kim and Sang-Jip Nam and Boon Jo Rho and Heonjoong Kang},
  journal={Journal of natural products},
  year={2012},
  volume={75 12},
  pages={2049-54}
}
Six new (1, 2, and 5-8) and three known (3, 4, and 9) butenolide metabolites were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 μM. Cadiolides 5-9 in… CONTINUE READING
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