Antibacterial antisense.

  title={Antibacterial antisense.},
  author={Bruce L. Geller},
  journal={Current opinion in molecular therapeutics},
  volume={7 2},
The concept of using antisense antibiotics is revolutionary. Instead of targeting proteins or macromolecular complexes, as do traditional antibiotics, antisense oligomers target specific genes, rRNA or mRNA, and inhibit expression of the targeted sequence. Recent advances have shown that two types of antisense oligomer, peptide nucleic acids and phosphorodiamidate morpholino oligomers (PMOs), inhibit gene expression in a sequence-specific and dose-dependent manner at low micromolar… CONTINUE READING