Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis

@inproceedings{Yang2017AntibacterialAD,
  title={Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis},
  author={Na Yang and Xuehui Liu and D. B. Teng and Zhanzhan Li and Xiumin Wang and Ruoyu Mao and Xiao Wang and Ya Qun Hao and Jianhua Wang},
  booktitle={Scientific Reports},
  year={2017}
}
NZ17074 (N1), an arenicin-3 derivative isolated from the lugworm, has potent antibacterial activity and is cytotoxic. To reduce its cytotoxicity, seven N1 analogues with different structures were designed by changing their disulfide bonds, hydrophobicity, or charge. The “rocket” analogue-N2 and the “kite” analogue-N6 have potent activity and showed lower cytotoxicity in RAW264.7 cells than N1. The NMR spectra revealed that N1, N2, and N6 adopt β-sheet structures stabilized by one or two… CONTINUE READING