Antibacterial and anticholinesterase activities of aplysamine-4, a bromotyrosine-derived metabolite of a Red Sea marine sponge.

@article{Sepi2001AntibacterialAA,
  title={Antibacterial and anticholinesterase activities of aplysamine-4, a bromotyrosine-derived metabolite of a Red Sea marine sponge.},
  author={Kristina Sep{\vc}i{\'c} and Ines Mancini and Iztok Vidic and R Franssanito and Francesco Pietra and Peter Ma{\vc}ek and Tom Turk},
  journal={Journal of natural toxins},
  year={2001},
  volume={10 3},
  pages={181-91}
}
Aplysamine-4, a metabolite of likely bromotyrosine biogenesis, was isolated from an unidentified verongid sponge from the Red Sea. The compound was identified by heteronuclear magnetic resonance experiments, and by electrospray ionization tandem mass spectrometry. The compound exhibited moderate inhibitory activity on several Gram positive and Gram negative bacteria, and was also found to be a non-competitive reversible inhibitor of acetylcholinesterase. At pH 7.4, a Ki value of 16 and 2 microM… CONTINUE READING