Antibacterial and Antifungal Activities of New Acylated Derivatives of Epigallocatechin Gallate

@inproceedings{Matsumoto2012AntibacterialAA,
  title={Antibacterial and Antifungal Activities of New Acylated Derivatives of Epigallocatechin Gallate},
  author={Yoshimi Matsumoto and Kunihiro Kaihatsu and Kunihiko Nishino and Miho Ogawa and Nobuo Kato and Akihito Yamaguchi},
  booktitle={Front. Microbio.},
  year={2012}
}
(-)-Epigallocatechin-3-O-gallate (EGCG) has useful antiviral, antimicrobial, antitoxin, and antitumor properties. Previously, Mori et al. (2008) found that addition of long acyl chains (C16-18) to EGCG enhanced its anti-influenza virus activity up to 44-fold. The chemical stability of EGCG against oxidative degradation was also enhanced by acylation. We further evaluated the in vitro activity spectrum of the EGCG derivatives against a wide range of bacteria and fungi. A series of EGCG O-acyl… CONTINUE READING