Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus)
@article{Mamo2019AntibacterialAA, title={Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus)}, author={Jermen Mamo}, journal={Current Trends in Biomedical Engineering \& Biosciences}, year={2019} }
Bromelain is an extract isolated from pineapple (Ananas comosus) mainly containing proteinase. It is a crude, aqueous extract from the stems and fruits of pineapples (Ananas comosus) derived from Bromeliaceae family. It has showed significant antibacterial activity against gram negative and gram positive bacteria such as Bacillus subtilis, Streptococcus pyogenes, Corynebacterium spp, Streptococcus sanguis (10556 ATCC), Enterococcus faecalis, Escherichia coli, Proteus spp and Pseudomonas…
8 Citations
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References
SHOWING 1-10 OF 48 REFERENCES
Antimicrobial Effects of Crude Bromelain Extracted from Pineapple Fruit (Ananas comosus (Linn.) Merr.).
- Biology
- 2015
Crude bromelain seems to be more effective in inhibiting gram positive bacteria than gram negative, and may be an effective antimicrobial agent against E. coli and Proteus spp.
In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.
- Medicine, BiologyPlanta medica
- 2007
Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU, and the unchanged tumor progression in the metastatic model suggests that the antimetastatic action results from a mechanism independent of the primary antitumoral effect.
Bromelain A Cysteine Protease: Helps To Reduce Infection Caused By Acinetobacter spp., A Nosocomial Pathogen.
- Biology, Medicine
- 2014
The antibacterial activity of bromelain extract was foun d against Acinetobacter spp by agar well diffusion method and AcinetOBacter isolates checked for lectin a ctivity.
Antibacterial activity of papain and bromelain on Alicyclobacillus spp.
- Medicine, ChemistryInternational journal of food microbiology
- 2016
Antibacterial Screening of Crude Extract of Oven-Dried Pawpaw and Pineapple
- 2015
Epidemiological surveillance of antimicrobial resistance is indispensable for empirically treating infections, implementing resistance, control measures and preventing the spread of antimicrobial…
ANTI-METASTATIC MECHANISM AND EFFICACY OF BROMELAIN
- Biology, Medicine
- 2015
The safety and efficacy of bromelain in cancer treatment is focused on and comparing it with other chemotherapeutic agents.
Properties and Therapeutic Application of Bromelain: A Review
- Medicine, BiologyBiotechnology research international
- 2012
Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics.
Plant Mediated Synthesis Of Gold Nanoparticles Using Fruit Extracts Of Ananas Comosus (L.) (Pineapple) And Evaluation Of Biological Activities
- Chemistry
- 2013
Plant mediated synthesis of metallic nanoparticles is an increasing commercial demand due to the wide applicability in various areas such as electronics, catalysis, chemistry, energy, cosmetics and…
Debridement Applications of Bromelain: A Complex of Cysteine Proteases from Pineapple
- Biology
- 2017
There are many types of proteases in the nature, since they represent about 2% of protein coding genes and plants are excellent sources of proteolytic enzymes with great activity and stability, and Therapeutic enzymes are the major biopharmaceuticals.
Bromelain Production: Current Trends and Perspective
- Medicine
- 2012
This review aims at presenting a detailed account on the level of achievement on bromelain production from the conventional methods and the current trends and the progress made in the production of recombinant stem bromelsain in Escherichia coli.