Antibacterial agents that inhibit two-component signal transduction systems.

  title={Antibacterial agents that inhibit two-component signal transduction systems.},
  author={John F. Barrett and Ra{\'u}l M. Goldschmidt and Laura E Lawrence and Barbara Foleno and Renwei Chen and Joe Demers and Sherida Johnson and Rahul Kanojia and James M. Fernandez and Joel Bernstein and Louise Licata and Anthony P. Donetz and Sui Huang and Dennis J Hlasta and Mark J Macielag and Kwasi A. Ohemeng and Rosalie Fr{\'e}chette and Marybeth Frosco and Dieter H. Klaubert and John M. Whiteley and Li-Sheng Wang and James A. Hoch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 9},
A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of hydrophobic tyramines, in addition to being a potent bactericidal Gram-positive antibacterial, inhibits the autophosphorylation of kinase A of the KinA::Spo0F two-component signal transduction system in vitro. Analogs of RWJ-49815 vary greatly in their ability to inhibit growth of bacteria and this ability correlates directly with their activity… CONTINUE READING
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