Antibacterial activity of two canthin‐6‐one alkaloids from Allium neapolitanum

@article{ODonnell2007AntibacterialAO,
  title={Antibacterial activity of two canthin‐6‐one alkaloids from Allium neapolitanum},
  author={Gemma O'Donnell and Simon Gibbons},
  journal={Phytotherapy Research},
  year={2007},
  volume={21}
}
The emergence of multidrug‐resistant strains of many human pathogens has led to an urgent need for the discovery and development of new antimicrobial agents. As part of an ongoing investigation into the antibacterial properties of the Alliaceae, the isolation of 1 (canthin‐6‐one), 2 (8‐hydroxy‐canthin‐6‐one) and 3 (5(ζ)‐hydroxy‐octadeca‐6(E)‐8(Z)‐dienioc acid)) from A. neapolitanum, a perennial bulbous herb found in open pastures of the Mediterranean is reported. Compounds 1 and 2 were isolated… 
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61 Citations
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61 Citations

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Citation Type

Synthesis and Evaluation of Ester Derivatives of 10-Hydroxycanthin-6-one as Potential Antimicrobial Agents
TLDR
7s emerged as a promising lead compound for the development of novel canthine-6-one antimicrobial agents, and showed the best inhibitory activity against all the tested bacteria.
Canthin‐4‐ones as Novel Antibacterial Agents
TLDR
In vitro screening for antimicrobial activity revealed that two 5‐substituted canthin‐4‐ones exhibit significant activity against Streptococcus entericus coupled with high selectivity and the lack of cytotoxicity against mammalian cells.
Anti-inflammatory Effects of Canthin-6-one Alkaloids from Ailanthus altissima.
TLDR
Data suggest that CO, but not 5-HCO with a hydroxyethyl moiety on the D ring, has potent anti-inflammatory activity in LPS-stimulated macrophages through the downregulation of both the NF-κB and the Akt pathway.
Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
TLDR
The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity, and the identities of the known compounds were further confirmed by comparison of their data with those reported in the literature.
Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones.
Synthesis and antibacterial activity of C2 or C5 modified and D ring rejiggered canthin-6-one analogues.
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
TLDR
Methyl disulfides are novel scaffolds which could lead to the development of new drugs against tuberculosis (TB), and their ability to inhibit mycobacterial drug efflux and biofilm formation is suggested.
Antitubercular potential of plants: A brief account of some important molecules
TLDR
This review gives concise up‐to‐date information regarding the chemistry and pharmacology of plant‐based leads and some insight into their structure–activity relationship.
Composition of the Essential Oil of Allium neapolitanum Cirillo Growing Wild in Sicily and its Activity on Microorganisms Affecting Historical Art Crafts.
TLDR
The essential oil of the aerial parts of Allium neapolitanum Cirillo collected in Sicily showed good antimicrobial activity against 11 strains of test microorganisms, including several species infesting historical material.
Canthin-6-one displays antiproliferative activity and causes accumulation of cancer cells in the G2/M phase.
TLDR
The data suggest that the primary effect of canthin-6-one (1) is antiproliferative, possibly by interfering with the G2/M transition, and that proapoptotic effects might result from this disturbance of the cell cycle.
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