Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure.

@article{Strub1996AntibacterialAO,
  title={Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure.},
  author={Jean Marc Strub and Patrick Hubert and G{\'e}rard Nullans and Dominique Aunis and Marie-H{\'e}l{\`e}ne Metz-Boutigue},
  journal={FEBS letters},
  year={1996},
  volume={379 3},
  pages={273-8}
}
Amongst the chromogranin B (CGB) derived fragments naturally generated in bovine chromaffin granules and detected in the extracellular space, we recently identified a major peptide corresponding to the 614-626 sequence of CGB. This peptide, named secretolytin, shared an interesting sequence homology with the lytic domain of cecropins and displayed a potent antibacterial activity. The aim of the present study was to determine the structural features of secretolytin necessary for this biological… CONTINUE READING

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