Antibacterial activity of linear peptides spanning the carboxy-terminal β-sheet domain of arthropod defensins

  title={Antibacterial activity of linear peptides spanning the carboxy-terminal β-sheet domain of arthropod defensins},
  author={J. Varkey and S. Singh and R. Nagaraj},
  • J. Varkey, S. Singh, R. Nagaraj
  • Published 2006
  • Biology, Medicine
  • Peptides
  • The antibacterial activity of peptides without disulfide bridges, spanning the carboxy-terminal segment of arthropod defensins, has been investigated. Although all the peptides have net positive charges, they exhibited varying antibacterial potencies and spectra. Atomic force and fluorescence microscopic analyses indicate that the peptides exert their activity by permeabilizing the outer and inner membranes of Gram-negative bacteria such as Escherichia coli. It appears that the plasticity… CONTINUE READING
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