Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

  title={Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria},
  author={Christoph M Schempp and Klaus Pelz and A Wittmer and Erwin Sch{\"o}pf and Jan C. Simon},
  journal={The Lancet},

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

Hyperforin, rather than hypericin as originally thought, has emerged as one of the major constituents responsible for antidepressant activity, and further research is required to determine which other constituents contribute to the antidepressant effect.

Investigating the Effectiveness of St John's Wort Herb as an Antimicrobial Agent against Mycobacteria

Investigation of the effectiveness of the Hypericum perforatum herb (commonly known as St John's wort; SJW) in its growth inhibition of mycobacteria found it effective at inhibiting five nonpathogenic Mycobacterium isolates and Bacillus subtilis, but not Escherichia coli.

Plants as a Source of Bacterial Resistance Modulators and Anti-Infective Agents

The activities of plant-derived antibacterials show that there are many potential new classes of antibacterial agents which should undergo further cytotoxicity, microbial specificity and preclinical studies.

Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

The results have shown that the newly developed HPE incorporated alginate films are a candidate as antibacterial, and antioxidant wound dressing for use on burn or excision wounds.

Antibacterial Effect of Hypericum Perforatum and Calophyllum Inophyllum Against Some Bacteria Causing Infections in Cesarean and Episiotomy Wounds

It was found out that Calophyllum inophyLLum was more effective on bacteria than Hypericum perforatum.


  • Jiasen Wang
  • Overcoming Antimicrobial Resistance of the Skin
  • 2021

Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort

Hyperforones A–J (1–10), ten degraded and reconstructed polycyclic polyprenylated acylphloroglucinols (PPAPs) with six different types of unusual architectures, were isolated from Hypericum perforatum to elucidate their origins and validate their structural assignments.



Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.

Since therapeutic doses of Hypericum extracts are much lower than that used in rats, a more sensitive LC/MS/MS method was developed and plasma levels of hyperforin could be followed for up to 24 h in healthy volunteers.

St John's wort for depression—an overview and meta-analysis of randomised clinical trials

There is evidence that extracts of Hypericum perforatum (St John's wort) are more effective than placebo for the treatment of mild to moderately severe depressive disorders.