Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

@article{Schempp1999AntibacterialAO,
  title={Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria},
  author={Christoph M Schempp and Klaus Pelz and A Wittmer and Erwin Sch{\"o}pf and Jan C. Simon},
  journal={The Lancet},
  year={1999},
  volume={353}
}
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206 Citations
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206 Citations

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

TLDR
Hyperforin, rather than hypericin as originally thought, has emerged as one of the major constituents responsible for antidepressant activity, and further research is required to determine which other constituents contribute to the antidepressant effect.

Investigating the Effectiveness of St John's Wort Herb as an Antimicrobial Agent against Mycobacteria

TLDR
Investigation of the effectiveness of the Hypericum perforatum herb (commonly known as St John's wort; SJW) in its growth inhibition of mycobacteria found it effective at inhibiting five nonpathogenic Mycobacterium isolates and Bacillus subtilis, but not Escherichia coli.

Plants as a Source of Bacterial Resistance Modulators and Anti-Infective Agents

TLDR
The activities of plant-derived antibacterials show that there are many potential new classes of antibacterial agents which should undergo further cytotoxicity, microbial specificity and preclinical studies.

Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

TLDR
The results have shown that the newly developed HPE incorporated alginate films are a candidate as antibacterial, and antioxidant wound dressing for use on burn or excision wounds.

Antibacterial Effect of Hypericum Perforatum and Calophyllum Inophyllum Against Some Bacteria Causing Infections in Cesarean and Episiotomy Wounds

TLDR
It was found out that Calophyllum inophyLLum was more effective on bacteria than Hypericum perforatum.

Cultivation of Hypericum Perforatum (St. John’s Wort) and Biotechnological Approaches for Improvement of Plant Raw Material Quality

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Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort

TLDR
Hyperforones A–J (1–10), ten degraded and reconstructed polycyclic polyprenylated acylphloroglucinols (PPAPs) with six different types of unusual architectures, were isolated from Hypericum perforatum to elucidate their origins and validate their structural assignments.

Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.

St. John’s Wort: A Therapeutic Herb to Be Cautioned for Its Potential Neurotoxic Effects and Major Drug Interactions

...

References

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Structure of a new topoisomerase II inhibitor BE 10988

The structure of hyperforin

Hypericum perforatum L.

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.

TLDR
Since therapeutic doses of Hypericum extracts are much lower than that used in rats, a more sensitive LC/MS/MS method was developed and plasma levels of hyperforin could be followed for up to 24 h in healthy volunteers.

St John's wort for depression—an overview and meta-analysis of randomised clinical trials

TLDR
There is evidence that extracts of Hypericum perforatum (St John's wort) are more effective than placebo for the treatment of mild to moderately severe depressive disorders.