Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification.

@article{ElGendy2015AntibacterialAO,
  title={Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification.},
  author={Bahaa El-Dien M El-Gendy and Mostafa E Rateb},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 16},
  pages={3125-8}
}
Nine diketopiperazines were characterized from the culture of marine fungal isolate MR2012 which based on DNA amplification and sequencing of the fungal internal transcribed spacer (ITS) region was identified as Aspergillus fumigatus. The isolated fungal metabolites 4-12 were unambiguously identified as a series of simple and re-arranged diketopiperazines by analysis of spectroscopic data. t-Butoxycarbonyl group (BOC) derivatization was used to separate the intractable mixture of 4 and 5. When… CONTINUE READING