Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with β-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii.

@article{Lee2017AntibacterialAO,
  title={Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with $\beta$-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii.},
  author={Spencer Lee and Ghaida Saleh Al Razqan and Dong Hyun Kwon},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2017},
  volume={24},
  pages={
          49-55
        }
}
BACKGROUND Infections caused by Acinetobacter baumannii were responsive to conventional antibiotic therapy. However, recently, carbapenem-associated multidrug resistant isolates have been reported worldwide and present a major therapeutic challenge. Epigallocatechin-3-Gallate (EGCG) extracted from green tea exhibits antibacterial activity. PURPOSE We evaluated the antibacterial activity of EGCG and possible synergism with antibiotics in carbapenem-associated multidrug resistant A. baumannii… 
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TLDR
Overall results demonstrate that the antibacterial activity of glutathione is clinically relevant and its synergism on antibiotics sensitizes clinical isolates of A. baumannii regardless of their resistance or susceptibility to antibiotics.
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TLDR
The importance of myxobacterial metabolites as promising antimicrobial agents against multi drug resistant A. baumannii infections is demonstrated.
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TLDR
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Synergistic antimicrobial activities of epigallocatechin gallate, myricetin, daidzein, gallic acid, epicatechin, 3‐hydroxy‐6‐methoxyflavone and genistein combined with antibiotics against ESKAPE pathogens
TLDR
Due to synergistic effects of natural phenolic compounds combined with antibiotics, pathogens that are already resistant to antibiotics could be resensitized as the results highlight the potential use of antibiotic-phytocompound-combinations for combating infections with multi-resistant pathogens.
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TLDR
Compound 9e showed the strong antibacterial activity against resistant Acinetobacter baumannii with rapid killing effect and no obvious triggering of the development of resistance.
Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
TLDR
The classic mechanisms of Acinetobacter AMR are summarized, along with newly-discovered genetic AMR factors and currently available antimicrobial adjuvants that can enhance drug efficacy in the treatment of A. baumannii infections.
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