Antibacterial activity and cytotoxicity analysis of halistanol trisulphate from marine sponge Petromica citrina.

  title={Antibacterial activity and cytotoxicity analysis of halistanol trisulphate from marine sponge Petromica citrina.},
  author={Palloma Rodrigues Marinho and Naomi Kato Simas and Ricardo Machado Kuster and Rafael Silva Duarte and S{\'e}rgio Eduardo Longo Fracalanzza and Davis Fernandes Ferreira and Maria Teresa Villela Romanos and Guilherme Muricy and Marcia Giambiagi-deMarval and Marinella Silva Laport},
  journal={The Journal of antimicrobial chemotherapy},
  volume={67 10},
OBJECTIVES An aqueous extract and fraction from the marine sponge Petromica citrina have antibacterial activity. We performed a chemical and biological characterization of the antibiotic substance from P. citrina and investigated its mode of action on Staphylococcus aureus cells. METHODS The inhibitory activity of the aqueous extract of P. citrina was determined against 14 bacteria belonging to type strains and clinical antibiotic-resistant strains. The aqueous extract was fractionated under… 

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