Antibacterial Effects of Silver Electrodes with Weak Direct Current

  title={Antibacterial Effects of Silver Electrodes with Weak Direct Current},
  author={Joseph A. Spadaro and Thomas J. Berger and S D Barranco and S E Chapin and Robert O. Becker},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={637 - 642}
Silver, platinum, gold, stainless-steel, and copper electrodes were used with low currents (0.02 to 20 μA/mm2) to explore their electrochemical effects on the growth of four bacterial species. In the higher current ranges, all electrodes inhibited growth at both poles, usually in conjunction with electrolytic break-down of the medium and severe corrosion of the metal. Silver, however, was extremely bacteriostatic, even at the lowest current, when used as the anode. Quantitative studies showed… Expand
Effect of electric current and silver electrodes on oral bacteria.
Zones of inhibition were evident at the positive electrode in all experiments and the widest zones were found at 1.5 μamp followed by 0.8 and 10.0 μamp. Expand
Some specific cellular effects of electrically injected silver and gold ions
Abstract We have shown that silver anodes are bacteriostatic in vitro at nominal current densities as low as 10 nA/mm 2 . Even antibiotic resistant strains are quite susceptible to the injectedExpand
Microbial Growth Inhibition by Alternating Electric Fields
Electric fields generated using insulated electrodes can inhibit the growth of planktonic Staphylococcus aureus and Pseudomonas aeruginosa and that the effect is amplitude and frequency dependent, with a maximum at 10 MHz. Expand
Inhibition of Enzyme Induction in E. Coli by Anodic Silver
A silver anode, but not a cathode, is bactericidal at microampere current levels because of the electrochemical reactions occurring at the metal electrode surface. This has been clinically useful asExpand
Antifungal Properties of Electrically Generated Metallic Ions
It is demonstrated that anodic silver (Ag+) at low direct currents had inhibitory and fungicidal properties, lower than those reported for other silver compounds. Expand
Electric Silver Antisepsis
A silver-coated fabric, designated IT, is discovered that is almost perfectly Faradaic in vitro up to 0.8 C and has potential for development as a charge-controlled topical antimicrobial agent. Expand
Direct-current bactericidal effect on intact skin
With an adhesive tape stripping technique on three sites on each of six subjects, it was determined that the bactericidal effect extended into the epidermis of the human back, probably mediated by local acidity generated at the surface of the positive carbon-containing electrodes. Expand
Electrochemical Methods for the Prevention of Microbial Fouling
Microbial fouling on metal surfaces is undesirable in many practical situations. The chemical and mechanical methods of fouling prevention include the use of biocidal chemicals, toxic paints,Expand
Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver–titanium implant system prototype
The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. Expand
Effects of direct electric current on the growth of microbes and their susceptibility to antibiotics
Abstract The in vitro effect of weak constant direct electric current on the growth of the bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis , and CandidaExpand


Lethal effects of electric current on Escherichia coli.
An attempt has been made to use low-voltage alternating current to kill microorganisms such as Escherichia coli using unalterable electrodes in the presence of chlorides in the medium. Expand
Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa.
The data suggest that inhibition of bacterial growth results from interference of DNA function by binding of silver ions along the helical chain. Expand
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected. Expand
Silver Sulfadiazine: Effect on the Ultrastructure of Pseudomonas aeruginosa
Pseudomonas aeruginosa exposed to silver sulfadiazine showed distorted in shape, and structures protruded from the cell surface; rather, such cells are characterized by large, central aggregations of nuclear material. Expand
Silver Sulfadiazine: Interaction with Isolated Deoxyribonucleic Acid
Silver sulfadiazine (AgSu) was found to interact with isolated deoxyribonucleic acid (DNA) to form nondissociable complexes. These complexes differ in physical and chemical properties from those thatExpand
Electrical effects on E. coli growth rates
  • Proc. Soc. Exp. Biol. Med
  • 1972
On the ni'4e of action of silver stilfadiazine
  • Pathol. Microbiol
  • 1972
Changes in bacterial sensitivity to antibiotics under the action of constant electric current and products of medium electrolysis
  • Antibiotiki
  • 1971