Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo

@inproceedings{Cao2012AntibacterialAA,
  title={Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo},
  author={Luyang Cao and Chao Zhou and Zhongjie Li and Zheng Fan and Yu Song and Yingliang Wu and Zhijian Cao and Wenxin Li},
  booktitle={PloS one},
  year={2012}
}
BmKn2 is an antimicrobial peptide (AMP) characterized from the venom of scorpion Mesobuthus martensii Karsch by our group. In this study, Kn2-7 was derived from BmKn2 to improve the antibacterial activity and decrease hemolytic activity. Kn2-7 showed increased inhibitory activity against both gram-positive bacteria and gram-negative bacteria. Moreover, Kn2-7 exhibited higher antibacterial activity against clinical antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus… CONTINUE READING
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