Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved?

@inproceedings{Moreira2009AntiaversiveEO,
  title={Antiaversive Effects of Cannabinoids:  Is the Periaqueductal Gray Involved?},
  author={Fabricio A Moreira and Daniele Cristina Aguiar and Alline Cristina de Campos and S. F. Lisboa and Ana Luisa Bernardes Terzian and Leonardo L B M Resstel and F. S. Guimar{\~a}es},
  booktitle={Neural plasticity},
  year={2009}
}
Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli. The regions responsible for their effects, however, are still unclear. Cannabinoid type 1 (CB1) receptors are widely distributed in the central nervous system and are present in the periaqueductal gray (PAG), a midbrain structure closely involved in responses related to aversive states. Accordingly, exposure to stressful… CONTINUE READING
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