Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling.

@article{Wohlfart2008AntiatheroscleroticEO,
  title={Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling.},
  author={Paulus Wohlfart and Hui Min Xu and Alexandra Endlich and Alice Habermeier and Ellen Ildicho Closs and Thomas H{\"u}bschle and C Mang and Hartmut Strobel and Teri Suzuki and Hartmut Kleinert and Ulrich Foerstermann and Hartmut Ruetten and Huige Li},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 2},
  pages={370-9}
}
Many cardiovascular diseases are associated with reduced levels of bioactive nitric oxide (NO) and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase (eNOS uncoupling). In human endothelial EA.hy 926 cells, two small-molecular-weight compounds with related structures, 4-fluoro-N-indan-2-yl-benzamide (CAS no. 291756-32-6; empirical formula C16H14FNO; AVE9488) and 2,2-difluoro-benzo[1,3]dioxole-5-carboxylic acid indan-2-ylamide (CAS no. 450348-85-3; empirical formula… CONTINUE READING

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