Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.

  title={Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.},
  author={Eisuke Suganuma and Yiqin Zuo and Nobuhiko Ayabe and Ji Ma and Vladimir R. Babaev and Macrae F Linton and Sergio Fazio and Iekuni Ichikawa and Agnes B. Fogo and Valentina Kon},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={17 2},
Angiotensin II (Ang II) increases atherosclerotic cardiovascular disease. Renal damage that is characterized by activation of Ang II markedly potentiates the risk for atherosclerosis, even in the setting of subtle renal impairment. Therefore, whether antagonism of Ang II actions can modify atherosclerosis in a model of mild renal impairment was examined. Apolipoprotein E-deficient spontaneously hyperlipidemic mice underwent uninephrectomy (UNx) or sham operation (sham) followed by treatment… CONTINUE READING