Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit.

@article{Park2004AntiarthriticEO,
  title={Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit.},
  author={Hye Ji Park and Seong Ho Lee and Dong Ju Son and Ki-Wan Oh and Ki Hyun Kim and Ho Sueb Song and Goon Joung Kim and Goo Taeg Oh and Do-Young Yoon and Jin Tae Hong},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 11},
  pages={3504-15}
}
OBJECTIVE To investigate the molecular mechanisms of the antiarthritic effects of bee venom (BV) and melittin (a major component of BV) in a murine macrophage cell line (Raw 264.7) and in synoviocytes obtained from patients with rheumatoid arthritis. METHODS We evaluated the antiarthritic effects of BV in a rat model of carrageenan-induced acute edema in the paw and in a rat model of chronic adjuvant-induced arthritis. The inhibitory effects of BV and melittin on inflammatory gene expression… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Similar Papers

Loading similar papers…