Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker.

  title={Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker.},
  author={Gregory N. Beatch and Saju T Abraham and Bernard A. MacLeod and Nami Yoshida and Michael A. Walker},
  journal={British journal of pharmacology},
  volume={102 1},
1. Rats were used to evaluate the antiarrhythmic properties of tedisamil, a novel agent with the electrophysiological properties of a Class III antiarrhythmic drug. Tedisamil was tested against coronary artery occlusion-induced arrhythmias in conscious animals. 2. The actions of tedisamil on the ECG, as well as responses to electrical stimulation, were compared with those on the configuration of epicardial intracellular action potentials recorded in vivo. 3. Tedisamil (1-4 mg kg-1, i.v.) caused… CONTINUE READING


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