Antiarrhythmic potency of naloxone determined by a screening test using the isolated ischaemic perfused rat heart preparation.

The antiarrhythmic potency of naloxone was determined by a screening test using the isolated ischaemic perfused rat heart preparation. The cardiac antiarrhythmic potency CAP50 with 95% confidence limit was 818 nmole/heart (646-985) and relative potency 0.22 compared with 0.35, 0.51 and 1.0 for lidocaine, quinidine and propranolol, respectively. These values… CONTINUE READING