Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats.

@article{krabalov2012AntiarrhythmicEO,
  title={Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats.},
  author={Jitka {\vS}krabalov{\'a} and Jan Neck{\'a}ř and Lucie Hejnova and Iveta Bartoňov{\'a} and Franti{\vs}ek Kol{\'a}ř and Jiri Novotny},
  journal={Pharmacological reports : PR},
  year={2012},
  volume={64 2},
  pages={
          351-9
        }
}
BACKGROUND Morphine is often administered to patients for pain management, but it is also recommended to ameliorate some types of cardiovascular diseases. Nevertheless, there is a lack of information regarding the effect of prolonged morphine treatment on myocardial adenylyl cyclase (AC) signaling, which plays an important role in regulating heart function. METHOD The present work has investigated the consequences of 10-day administration of high morphine doses (10 mg/kg per day) to adult… CONTINUE READING
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