Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization.

@article{Tang2007AntiarrhythmicEO,
  title={Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization.},
  author={Qizhu Tang and Ji Huang and Haiyan Qian and Li Chen and Teng Wang and Haining Wang and Difei Shen and Hui Wu and Ran Xiong},
  journal={Life sciences},
  year={2007},
  volume={80 7},
  pages={601-8}
}
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are known to inhibit cholesterol biosynthesis and prevent inflammation and oxidative stress. To explore the effects of atorvastatin on inflammatory progression and major cardiac electrophysiological changes in myocarditis, we used an animal model of experimental autoimmune myocarditis (EAM). In this model, BALB/c mice were treated with atorvastatin and we evaluated the levels of inflammation markers and currents… CONTINUE READING

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