Corpus ID: 39460572

Antiarrhythmic and antihypertensive activity of some xanthone derivatives.

@article{Marona2008AntiarrhythmicAA,
  title={Antiarrhythmic and antihypertensive activity of some xanthone derivatives.},
  author={H. Marona and T. Librowski and M. Cegła and C. Erdoğan and N. Sahin},
  journal={Acta poloniae pharmaceutica},
  year={2008},
  volume={65 3},
  pages={
          383-90
        }
}
Some of appropriate aminoisopropanoloxy derivatives of 4-xanthone were tested for their effect on circulatory system (protection against adrenaline-, barium-, and calcium chloride-induced arrhythmias, as well as hypotensive activity and acute toxicity). The most prominent hypotensive activity was demonstrated by (+/-)-1-[4-(hydroxyethyl)-1-(piperazinyl)]-3-(4-xanthonoxy)-2-propanol dihydrochloride (II), which diminished arterial blood pressure by about 40% during one hour observation. The… Expand
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