Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model.

@article{Dharmapuri2009AntiapoptoticSI,
  title={Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model.},
  author={Sridhar Dharmapuri and Luigi Aurisicchio and Antonella Biondo and Natalie Welsh and Gennaro Ciliberto and Nicola La Monica},
  journal={Human gene therapy},
  year={2009},
  volume={20 6},
  pages={589-97}
}
In vivo electroporation of plasmid DNA (DNA-EP) is an efficient and safe method for vaccines. It results in increased DNA uptake, enhances protein expression, and augments immune responses to the target antigen in a variety of species. To further improve the efficacy of DNA-EP, we evaluated small interfering RNA (siRNA) sequences targeting apoptotic genes as an adjuvant to cancer vaccine. Bak1 or Casp8 siRNA was coadministered with plasmid DNA encoding the extracellular and transmembrane… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Vaccines for tumour prevention

View 3 Excerpts
Highly Influenced

RNA interference.

Pharmacogenomics • 2005
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…