Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.

  title={Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.},
  author={Charles L Howe and Allan J. Bieber and Arthur E. Warrington and Larry R. Pease and Moses Rodriguez},
  journal={Neurobiology of disease},
  volume={15 1},
Stabilizing the survival of oligodendrocytes and oligodendrocyte precursors within and near lesions in patients suffering from multiple sclerosis (MS) and other demyelinating diseases is an important therapeutic goal. Previous studies have identified a human-derived monoclonal IgM antibody designated rHIgM22 that induces remyelination in a mouse model of MS. We provide evidence that this antibody, directed against myelin, induces antiapoptotic signaling in premyelinating oligodendrocytes and… CONTINUE READING
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