Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease.

  title={Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease.},
  author={Veerappan Venkatesh Gobi and S. Rajasankar and William Moses Swaminathan Johnson and K. Prabu and Muthu Ramkumar},
  journal={Frontiers in bioscience},
  • Veerappan Venkatesh Gobi, S. Rajasankar, +2 authors Muthu Ramkumar
  • Published 2019
  • Medicine, Biology
  • Frontiers in bioscience
  • Rotenone is a pesticide that has been shown to induce the pathological symptoms of Parkinson's disease (PD) in both cellular and animal models. In this study, we investigated the protective effect of Agaricus blazei extract on rotenone-induced dopaminergic degeneration and apoptosis in mice model. A. blazei extract blocked the rotenone-mediated diminution of   dopamine transporter (DAT)  and vesicular monoamine transporter 2 (VMAT 2) expression and  the downregulation of Bcl-2 and the… CONTINUE READING
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