Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation.

@article{Filomeni2005AntiapoptoticRT,
  title={Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation.},
  author={Giuseppe Filomeni and Katia Aquilano and Giuseppe Rotilio and Maria Rosa Ciriolo},
  journal={Antioxidants & redox signaling},
  year={2005},
  volume={7 3-4},
  pages={
          446-55
        }
}
Alteration of glutathione (GSH) homeostasis represents one of the earliest events during the commitment of stress-induced apoptosis. Extrusion of GSH into the extracellular milieu, in response to several oxidative stimuli, has been suggested as a molecular switch triggering apoptosis. However, chemical depletion of GSH does not induce cell death even though cytochrome c release from mitochondria has been observed. Here we report that U937 cells treated with buthionine sulfoximine (BSO) are able… CONTINUE READING
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