Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies
@article{Drzyzga2009AntiapoptoticAN, title={Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies}, author={Łukasz Drzyzga and Agnieszka Marcinowska and Ewa Obuchowicz}, journal={Brain Research Bulletin}, year={2009}, volume={79}, pages={248-257} }
82 Citations
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence
- Psychology, BiologyCurrent neuropharmacology
- 2011
Preclinical and clinical studies aimed at disclosing the role of neurotrophins in the pathophysiological mechanisms of depression and the mode of action of antidepressants, which favour the neurotrophic/neurogenic hypothesis are reviewed.
Modulation of microglial activation by antidepressants
- Biology, PsychologyJournal of psychopharmacology
- 2022
The hypothesis that the action of at least certain classes of antidepressants may involve regulation of microglial activation, especially when in presence of increased levels of inflammation, is supported.
Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review
- Psychology, BiologyThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- 2012
The importance of the neurogenesis hypothesis of depression and antidepressant action lies in stimulating further research into the possible roles played by the new neurons and synapses generated, as well as investigating the role of antidepressant drugs in the reversal of some but not all symptoms in depression.
Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
- Biology, MedicinePharmacology research & perspectives
- 2016
The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system.
Role of zinc in the development and treatment of mood disorders
- Psychology, MedicineCurrent opinion in clinical nutrition and metabolic care
- 2010
Zinc administration improves the efficacy of antidepressant drugs in depressed patients and may have a particular role to play in treatment-resistant patients, and data reviewed here show that zinc may also be important in their treatment.
Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression
- Biology, PsychologyMolecules
- 2014
It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression.
Molecular Mechanisms Underlying the Anti-depressant Effects of Resveratrol: a Review
- Biology, PsychologyMolecular Neurobiology
- 2017
Resveratrol may be viewed as a potential anti-depressant agent, as well as may serve as a model of molecule to be modified aiming to ameliorate depressive symptoms in humans.
In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
- Biology, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2011
Role of brain-derived neurotrophic factor in the molecular neurobiology of major depressive disorder
- Psychology, BiologyTranslational perioperative and pain medicine
- 2017
The important role of BDNF in the progress of depression in animal models and patients with depressive disorders is described, and the detailed mechanisms related to depression and antidepressant responses are not fully understood.
Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms
- BiologyExpert review of neurotherapeutics
- 2013
The authors review their recent results on the molecular mechanisms by which MAO inhibitors prevent the cell death through the induction of antiapoptotic, prosurvival genes in selegiline and rasagiline.
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