Antiapoptotic activities of Leukemia Inhibitory Factor ( LIF ) and Vascular Endothelial Growth Factor ( VEGF ) in hypoxic human trophoblast depend on gestational age

@inproceedings{Szukiewicz2010AntiapoptoticAO,
  title={Antiapoptotic activities of Leukemia Inhibitory Factor ( LIF ) and Vascular Endothelial Growth Factor ( VEGF ) in hypoxic human trophoblast depend on gestational age},
  author={Dariusz Szukiewicz and Michal Pyzlak and Aleksandra Stangret and Dariusz Bialoszewski and Slawomir Maslinski},
  year={2010}
}
Susceptibility of the human trophoblast to apoptosis is changing throughout pregnancy. Invasiveness and differentiation of the trophoblastic cells may be severely modulated by hypoxia, well-known apoptosis inducer. From the other hand, local antiapoptotic activities of Leukemia Inhibitory Factor (LIF) and Vascular Endothelial Growth Factor (VEGF) may affect the course of hypoxia-induced programmed cell death. In this study, we examined comparatively (first trimester vs. term pregnancy), whether… CONTINUE READING