Antiapoptotic BCL-2 is required for maintenance of a model leukemia.

  title={Antiapoptotic BCL-2 is required for maintenance of a model leukemia.},
  author={Anthony Letai and Mia D. Sorcinelli and Caroline F Beard and S Stanley J. Korsmeyer},
  journal={Cancer cell},
  volume={6 3},
Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To test this, we generated mice expressing a conditional BCL-2 gene and constitutive c-myc that develop lymphoblastic leukemia. Eliminating BCL-2 yielded rapid loss of leukemic cells and significantly prolonged survival, formally validating BCL-2 as a rational… CONTINUE READING

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A-385358, a potent BCL-XL/BCL-2 antagonist induces apoptosis in tumor cell lines

  • B. Belli, T. Deckwerth, +7 authors P Hajduk
  • Proc. AACR 44
  • 2003
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