Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan

@article{Rodgers1994AntianxietyAB,
  title={Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan},
  author={R. John Rodgers and J. C. Cole and A. Davies},
  journal={Pharmacology Biochemistry and Behavior},
  year={1994},
  volume={48},
  pages={959-963}
}
Flesinoxan is a potent and selective 5-HT1A receptor agonist. In this study, the effects of this compound on behavior in the murine elevated plus-maze have been assessed using a recently developed ethological scoring method. Results show that, at low doses (0.1-0.5 mg/kg), flesinoxan inhibited risk assessment behaviors (stretched attend postures and closed arm returns) indicative of a reduction in anxiety. These effects were maintained at a higher dose of 1.0 mg/kg, which also increased percent… Expand
The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat
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TLDR
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Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission
TLDR
As for selective 5- HT re-uptake inhibitors, monoamine oxidase inhibitors and 5-HT1A receptor agonists, flesinoxan produced most of the adaptive changes exerted by these antidepressant drugs on the 4-HT system and the marked potency and the long dissociation constant of fles inoxan for the 5-ht1A receptors may account for the latter discrepancy. Expand
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