Antiangiogenic therapy: a universal chemosensitization strategy for cancer?

  title={Antiangiogenic therapy: a universal chemosensitization strategy for cancer?},
  author={Robert S. Kerbel},
  volume={312 5777},
For more than 50 years, a major goal of research in cancer therapeutics has been to develop universally effective agents that render cancer cells more sensitive to cytotoxic chemotherapy without substantially increasing toxicity to normal cells. The results of recent clinical trials indicate that certain antiangiogenic drugs may produce this long-sought effect. Here, I describe three distinct mechanisms that may help to explain the chemosensitizing activity of these drugs: normalizing tumor… CONTINUE READING
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