Antiangiogenic therapy: a universal chemosensitization strategy for cancer?

@article{Kerbel2006AntiangiogenicTA,
  title={Antiangiogenic therapy: a universal chemosensitization strategy for cancer?},
  author={Robert S. Kerbel},
  journal={Science},
  year={2006},
  volume={312 5777},
  pages={
          1171-5
        }
}
For more than 50 years, a major goal of research in cancer therapeutics has been to develop universally effective agents that render cancer cells more sensitive to cytotoxic chemotherapy without substantially increasing toxicity to normal cells. The results of recent clinical trials indicate that certain antiangiogenic drugs may produce this long-sought effect. Here, I describe three distinct mechanisms that may help to explain the chemosensitizing activity of these drugs: normalizing tumor… CONTINUE READING
Highly Cited
This paper has 356 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 203 extracted citations

Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 10 Excerpts
Highly Influenced

Aflibercept a new target therapy in cancer treatment: a review.

Critical reviews in oncology/hematology • 2015
View 2 Excerpts
Highly Influenced

Angiogenesis Protocols

Methods in Molecular Biology • 2009
View 3 Excerpts
Highly Influenced

357 Citations

02040'08'11'14'17
Citations per Year
Semantic Scholar estimates that this publication has 357 citations based on the available data.

See our FAQ for additional information.