Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.

  title={Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.},
  author={Amudhan Venkateswaran and Yerramreddy Thirupathi Reddy and Vijaykumar N Sonar and Venkatraj Muthusamy and Peter A. Crooks and Michael L Freeman and Konjeti Raja Sekhar},
  journal={Bioorganic & medicinal chemistry letters},
  volume={20 24},
In the past half century research efforts have defined a critical role for angiogenesis in tumor growth and metastasis. We previously reported that inhibition of a novel target, ENOX1, by a (Z)-2-benzylindol-3-ylmethylene) quinuclidin-3-ol, suppressed tumor angiogenesis. The present study was undertaken in order to establish structure-activity relationships for quinuclidine analogs. The angiogenesis inhibiting activity of a series of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene… CONTINUE READING