Antiangiogenic properties of gold nanoparticles.

@article{Mukherjee2005AntiangiogenicPO,
  title={Antiangiogenic properties of gold nanoparticles.},
  author={Priyabrata Mukherjee and Resham Bhattacharya and Ping Wang and Ling Wang and Sujit Basu and Janice A. Nagy and Anthony J. Atala and Debabrata Mukhopadhyay and Shay Soker},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 9},
  pages={
          3530-4
        }
}
Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothelial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as… CONTINUE READING

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