Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors.

  title={Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors.},
  author={Andreas Peyrl and Monika Chocholous and Mark W Kieran and Amedeo A Azizi and Christina Prucker and Thomas Czech and Karin Ute Dieckmann and Maria-Theresa Schmook and Christine Haberler and Ulrike Leiss and Irene Slavc},
  journal={Pediatric blood & cancer},
  volume={59 3},
BACKGROUND Median survival time of recurrent embryonal brain tumors is short regardless of salvage chemotherapy used. An evolving alternative approach to conventional chemotherapy is to target neovascularization by interfering with tumor angiogenesis at various levels. PROCEDURE From November 2006 to December 2010, 16 patients (median age: 9 years) with recurrent (9 first, 7 multiple) embryonal brain tumors were treated with an antiangiogenic multidrug combination regimen (bevacizumab… CONTINUE READING
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