Antiangiogenic gene therapy.

@article{Folkman1998AntiangiogenicGT,
  title={Antiangiogenic gene therapy.},
  author={Judah M Folkman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={
          9064-6
        }
}
In a previous issue of the Proceedings, there are two reports of anti-tumor therapy in mice based on inhibition of angiogenesis by gene therapy. Lin et al. (1) used an adenoviral vector to deliver a recombinant Tie2 receptor that blocked activation of the Tie2 receptor on endothelial cells. A single i.v. injection of this construct resulted in a high circulating level of the soluble receptor protein (.1 mgyml) for 8 days. Growth of two different primary tumors was inhibited significantly… CONTINUE READING

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