Antiangiogenic gene therapy with systemically administered sFlt-1 plasmid DNA in engineered gelatin-based nanovectors

@article{Kommareddy2007AntiangiogenicGT,
  title={Antiangiogenic gene therapy with systemically administered sFlt-1 plasmid DNA in engineered gelatin-based nanovectors},
  author={Sushma Kommareddy and Mansoor M Amiji},
  journal={Cancer Gene Therapy},
  year={2007},
  volume={14},
  pages={488-498}
}
This study examined the potential of engineered gelatin-based nanoparticulate vectors for systemic delivery of therapeutic genes to human solid tumor xenografts in vivo. Plasmid DNA encoding for the soluble form of the extracellular domain of vascular endothelial growth factor receptor-1 (VEGF-R1 or sFlt-1) was encapsulated in the control and poly(ethylene glycol) (PEG)-modified gelatin-based nanoparticles. When the plasmid DNA was delivered in PEG-modified thiolated gelatin nanoparticles… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Gelatin nanoparticles and their biofunctionalization

  • S Kommareddy, DB Shenoy, M. Amiji
  • Biological and Pharmaceutical Nanomaterials,
  • 2005

Nanoparticulate carriers of gelatin and gelatin derivatives

  • S Kommareddy, DB Shenoy, M. Amiji
  • Biological and Pharmaceutical Nanomaterials
  • 2005

Similar Papers

Loading similar papers…